Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 8/20 | 0.44 |
| ▸ | FNTB | P49356 | 8/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NRAS | P01111 | 1/20 | 0.43 |
| ▸ | HRAS | P01112 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084727 | 0.86 | HTT (0.50) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7078625 | 0.85 | CYP11B1 (0.47) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7085607 | 0.84 | FNTA (0.51) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7083066 | 0.82 | KCNH2 (0.47) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7080044 | 0.81 | CYP11B1 (0.48) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7086262 | 0.79 | FNTA (0.45) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7174102 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL8498829 | 0.78 | FNTA (0.41) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7083324 | 0.78 | FNTA (0.49) | CYP11B1CYP11B2KCNH2FNTAFNTB | |
| SCHEMBL7084767 | 0.78 | FNTA (0.52) | CYP11B1CYP11B2FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200430-A4 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORP LTD (KR) | 2003-01-22 | — | — | EP | disclosed |
| EP-1200430-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION, LTD. (KR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009128-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION (KR) | 2001-02-08 | — | — | WO | disclosed |