Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | FNTA | P49354 | 11/20 | 0.47 |
| ▸ | FNTB | P49356 | 11/20 | 0.47 |
| ▸ | PGGT1B | P53609 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | NRAS | P01111 | 1/20 | 0.42 |
| ▸ | HRAS | P01112 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083324 | 0.96 | FNTA (0.49) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7173341 | 0.93 | CYP11B1 (0.44) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7178460 | 0.89 | FNTA (0.46) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7078782 | 0.89 | ALDH1A1 (0.45) | FNTAFNTBPGGT1BALDH1A1SMN1; SMN2 | |
| SCHEMBL7174102 | 0.88 | CYP11B1 (0.47) | KCNH2FNTAFNTBALDH1A1SMN1; SMN2 | |
| SCHEMBL7085607 | 0.87 | FNTA (0.51) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7078625 | 0.86 | CYP11B1 (0.47) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7076893 | 0.85 | ALDH1A1 (0.42) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7076127 | 0.85 | HTT (0.48) | KCNH2FNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL7084727 | 0.83 | HTT (0.50) | KCNH2FNTAFNTBPGGT1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200430-A4 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORP LTD (KR) | 2003-01-22 | — | — | EP | disclosed |
| EP-1200430-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION, LTD. (KR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009128-A1 | THIOUREA AND ISOTHIOUREA DERIVATIVES FOR INHIBITING RAS-TRANSFORMED CELL GROWTH | YUHAN CORPORATION (KR) | 2001-02-08 | — | — | WO | disclosed |