Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.66 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080951 | 0.94 | REN (0.57) | RENMCHR1GPBAR1 | |
| SCHEMBL7083333 | 0.94 | REN (0.57) | RENMCHR1 | |
| SCHEMBL7080438 | 0.92 | REN (0.61) | RENGPBAR1 | |
| SCHEMBL7080702 | 0.92 | REN (0.56) | RENMCHR1 | |
| SCHEMBL7081144 | 0.89 | REN (0.55) | RENGPBAR1 | |
| SCHEMBL7082567 | 0.88 | REN (0.49) | REN | |
| SCHEMBL7083259 | 0.88 | REN (0.53) | RENGPBAR1 | |
| SCHEMBL7074891 | 0.88 | REN (0.48) | REN | |
| SCHEMBL7075968 | 0.88 | REN (0.50) | REN | |
| SCHEMBL7076959 | 0.87 | REN (0.48) | RENMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |