Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14271500 | 0.83 | EGFR (0.46) | EGFRERBB2SMN1; SMN2KMT2APOLB | |
| SCHEMBL4956996 | 0.81 | EGFR (0.43) | EGFRERBB2L3MBTL1CFTRTP53 | |
| SCHEMBL7086157 | 0.79 | JMJD6 (0.34) | SMN1; SMN2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL4957675 | 0.75 | EGFR (0.49) | EGFRERBB2SMN1; SMN2KMT2APOLB | |
| SCHEMBL17582602 | 0.65 | SMN1; SMN2 (0.56) | EGFRERBB2SMN1; SMN2KMT2APOLB | |
| SCHEMBL15920987 | 0.63 | SMN1; SMN2 (0.61) | SMN1; SMN2KMT2APOLBF2RL3MAPK1 | |
| SCHEMBL1242317 | 0.62 | SMN1; SMN2 (0.49) | EGFRERBB2SMN1; SMN2KMT2APOLB | |
| SCHEMBL25604982 | 0.62 | MAPK1 (0.52) | EGFRERBB2SMN1; SMN2KMT2APOLB | |
| SCHEMBL3265402 | 0.62 | SMN1; SMN2 (0.60) | SMN1; SMN2KMT2APOLBMAPK1TDP1 | |
| SCHEMBL21332805 | 0.61 | SMN1; SMN2 (0.77) | SMN1; SMN2KMT2APOLBMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296678-A2 | VITRONECTIN RECEPTOR ANTAGONIST PHARMACEUTICALS FOR USE IN COMBINATION THERAPY | Bristol-Myers Squibb Pharma Company (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098294-A2 | VITRONECTIN RECEPTOR ANTAGONIST PHARMACEUTICALS FOR USE IN COMBINATION THERAPY | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-12-27 | — | — | WO | disclosed |
| EP-1140203-A2 | VITRONECTIN RECEPTOR ANTAGONIST PHARMACEUTICALS | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035488-A2 | VITRONECTIN RECEPTOR ANTAGONIST PHARMACEUTICALS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |