Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14504424 | 0.90 | SMN1; SMN2 (0.72) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL14504419 | 0.90 | SMN1; SMN2 (0.72) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL14504177 | 0.90 | SMN1; SMN2 (0.72) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL8051814 | 0.90 | HTT (0.72) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL2241510 | 0.83 | HTT (0.48) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL2241516 | 0.83 | HTT (0.48) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL12757927 | 0.83 | HTT (0.68) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL6272713 | 0.83 | SMN1; SMN2 (0.63) | HTTSMN1; SMN2NPSR1CTSLCTSB | |
| SCHEMBL6640516 | 0.82 | PDE4A (0.55) | HTTSMN1; SMN2NPSR1NUDT1HRH4 | |
| SCHEMBL2783836 | 0.82 | NUDT1 (0.51) | HTTSMN1; SMN2NPSR1CTSKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030148269-A1 | Centrifugally-enhanced method of determining ligand/target affinity | HOLZMAN THOMAS F (US) | 2003-08-07 | — | — | US | disclosed |
| EP-1161684-A1 | CENTRIFUGALLY-ENHANCED METHOD OF DETERMINING LIGAND/TARGET AFFINITY | ABBOTT LABORATORIES (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055625-A1 | CENTRIFUGALLY-ENHANCED METHOD OF DETERMINING LIGAND/TARGET AFFINITY | ABBOTT LABORATORIES (US) | 2000-09-21 | — | — | WO | disclosed |