Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluoxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 12/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
| ▸ | APLNR | P35414 | 1/20 | 1.00 |
| ▸ | CX3CR1 | P49238 | 1/20 | 1.00 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 1.00 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoxetine SCHEMBL3399076 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL33384 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL56333 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| R-Fluoxetine SCHEMBL3905325 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL8911991 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL33947 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL570572 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL8467346 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL8353 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| R-Fluoxetine SCHEMBL1200433 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655475-B | Preparation method of fluoxetine hydrochloride | 山东轩鸿生物医药有限公司 | 2024-12-31 | — | — | CN | disclosed |
| CN-116655475-A | Preparation method of fluoxetine hydrochloride | 山东轩鸿生物医药有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2018039526-A1 | TREATMENT OF NEURODEGENERATIVE DISORDERS AND PAIN | WRIGHT STATE UNIVERSITY (US) | 2018-03-01 | — | — | WO | disclosed |
| EP-0612242-B1 | USE OF THE PURE S(+) ISOMER OF FLUOXETINE FOR THE PREPARATION OF A MEDICAMENT AGAINST MIGRAINE HEADACHE | SEPRACOR INC (US) | 2003-07-09 | — | — | EP | disclosed |
| EP-1208838-A2 | Pure S(+)isomer fluoxetine | Sepracor Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0612242-A4 | METHODS AND COMPOSITIONS UTILIZING PURE S(+) ISOMER FLUOXETINE. | SEPRACOR INC (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5589511-A | Method for treating migraine headaches using optically pure S(+) fluoxetine | SEPRACOR INC. (US) | 1996-12-31 | — | — | US | disclosed |
| WO-1995028152-A1 | METHODS AND COMPOSITIONS FOR TREATING DEPRESSION AND OTHER DISORDERS USING OPTICALLY PURE S(+) FLUOXETINE | SEPRACOR INC. (US) | 1995-10-26 | — | — | WO | disclosed |
| EP-0612242-A1 | METHODS AND COMPOSITIONS UTILIZING PURE S(+) ISOMER FLUOXETINE | SEPRACOR, INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1994000416-A1 | PREPARATION OF N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPYLAMINE AND ACID ADDITION SALTS THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1994-01-06 | — | — | WO | disclosed |
| WO-1993009769-A1 | METHODS AND COMPOSITIONS UTILIZING PURE S(+) ISOMER FLUOXETINE | SEPRACOR, INC. (US) | 1993-05-27 | — | — | WO | disclosed |