Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluoxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 12/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
| ▸ | APLNR | P35414 | 1/20 | 1.00 |
| ▸ | CX3CR1 | P49238 | 1/20 | 1.00 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 1.00 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoxetine SCHEMBL3399076 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL33384 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL7081402 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL56333 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| R-Fluoxetine SCHEMBL3905325 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL33947 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL570572 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL8467346 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| Fluoxetine SCHEMBL8353 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A | |
| R-Fluoxetine SCHEMBL1200433 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC6A2MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0380924-A1 | Process for the preparation of fluoxetine hydrochloride | Magnone, Grato (IT) | 1990-08-08 | — | — | EP | claimed |
| US-20230402154-A1 | SYSTEM AND APPARATUS FOR ITEM MANAGEMENT | CHUDY GROUP LLC (US) | 2023-12-14 | — | — | US | disclosed |
| US-11756669-B2 | System and apparatus for item management | Chudy Group, LLC (US) | 2023-09-12 | — | — | US | disclosed |
| US-11705236-B2 | System and apparatus for item management | Chudy Group, LLC (US) | 2023-07-18 | — | — | US | disclosed |
| US-20220359059-A1 | SYSTEM AND APPARATUS FOR ITEM MANAGEMENT | CHUDY GROUP LLC (US) | 2022-11-10 | — | — | US | disclosed |
| US-11348675-B2 | System and apparatus for item management | Chudy Group, LLC (US) | 2022-05-31 | — | — | US | disclosed |
| US-11264124-B2 | System and apparatus for item management | Chudy Group, LLC (US) | 2022-03-01 | — | — | US | disclosed |
| US-20210090713-A1 | SYSTEM AND APPARATUS FOR ITEM MANAGEMENT | PARATA SYSTEMS, LLC | 2021-03-25 | — | — | US | disclosed |
| US-20200342972-A1 | SYSTEM AND APPARATUS FOR ITEM MANAGEMENT | PARATA SYSTEMS, LLC | 2020-10-29 | — | — | US | disclosed |
| US-10650921-B2 | System and apparatus for item management | Chudy Group, LLC (US) | 2020-05-12 | — | — | US | disclosed |
| US-20140261881-A1 | System and Apparatus for Item Management Including Item Detection | Chudy Group, LLC (US) | 2014-09-18 | — | — | US | disclosed |
| CN-103392963-A | High-potency sweetener for weight management and compositions sweetened therewith | COCA COLA CO | 2013-11-20 | — | — | CN | disclosed |
| CN-103392964-A | High-potency sweetener for weight management and compositions sweetened therewith | COCA COLA CO | 2013-11-20 | — | — | CN | disclosed |
| CN-103393068-A | High-potency sweetener for weight management and compositions sweetened therewith | COCA COLA CO | 2013-11-20 | — | — | CN | disclosed |
| US-20130218330-A1 | System and Apparatus for Item Management | Chudy Group, LLC (US) | 2013-08-22 | — | — | US | disclosed |
| CN-101312660-B | High-potency sweetener for weight management and compositions sweetened therewith | COCA COLA CO | 2013-07-17 | — | — | CN | disclosed |
| CN-101312660-A | High-potency sweetener for weight management and compositions sweetened therewith | COCA COLA CO (US) | 2008-11-26 | — | — | CN | disclosed |
| US-5668134-A | LOMEFLOXACIN HYDROCHLORIDE | G. D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5603917-A | RECORDING IN VIVO MEASUREMENTS OF INTENSITY OF MAGNETIC RESONANCE SIGNAL FROM XENOBIOTIC COMPOUND, DETERMINING CONCENTRATION BY COMPARISON OF SIGNAL INTENSITY WITH THAT OF STANDARD | BRACCO INTERNATIONAL B. V. (NL) | 1997-02-18 | — | — | US | disclosed |
| US-5468467-A | Methods for the in vivo measurement of the concentration of non-imaging nmr-detectable xenobiotic compounds | BRACCO INTERNATIONAL B.V. (NL) | 1995-11-21 | — | — | US | disclosed |