⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1545443 | 0.67 | — | — | |
| SCHEMBL1825647 | 0.60 | — | — | |
| SCHEMBL333404 | 0.60 | — | — | |
| SCHEMBL299712 | 0.60 | — | — | |
| SCHEMBL14953658 | 0.59 | — | — | |
| SCHEMBL1140396 | 0.59 | — | — | |
| Hydrochloric Acid SCHEMBL28422009 | 0.57 | — | — | |
| SCHEMBL4427147 | 0.55 | KDM4E (0.47) | — | |
| SCHEMBL7184246 | 0.55 | — | — | |
| SCHEMBL6125510 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334322-A1 | EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF | ALX Oncology Inc. (US) | 2024-03-13 | — | — | EP | claimed |
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | claimed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | claimed |
| US-5217975-A | AZABICYCLIC COMPOUNDS FOR TREATING DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1993-06-08 | — | — | US | claimed |
| EP-0402056-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | Beecham Group p.l.c. (GB) | 1990-12-12 | — | — | EP | claimed |
| EP-4334322-A1 | EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF | ALX Oncology Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| US-9187462-B2 | Substituted quinazolines as serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-11-17 | — | — | US | disclosed |
| EP-2739618-B1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-09-16 | — | — | EP | disclosed |
| US-20150087664-A1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2015-03-26 | — | — | US | disclosed |
| EP-2739618-A1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013020062-A1 | QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-02-07 | — | — | WO | disclosed |
| EP-0413545-B1 | Azabicyclic compounds | BEECHAM GROUP PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| US-5470859-A | Cognition activators for the central nervous system | BEECHAM GROUP P.L.C. (GB) | 1995-11-28 | — | — | US | disclosed |
| EP-0414394-B1 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1995-07-05 | — | — | EP | disclosed |
| US-5217975-A | AZABICYCLIC COMPOUNDS FOR TREATING DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1993-06-08 | — | — | US | disclosed |
| US-5157160-A | Treatment of diseases of the nervous system | BEECHAM GROUP P.L.C. (GB) | 1992-10-20 | — | — | US | disclosed |
| US-5043343-A | Certain 5-substituted-1-aza-bicyclo[3.3.3]heptanes and their pharmaceutical compositions and methods | BEECHAM GROUP P.L.C. (GB) | 1991-08-27 | — | — | US | disclosed |
| EP-0414394-A2 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1991-02-27 | — | — | EP | disclosed |
| EP-0413545-A2 | Azabicyclic compounds | Beecham Group p.l.c. (GB) | 1991-02-20 | — | — | EP | disclosed |
| EP-0402056-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | Beecham Group p.l.c. (GB) | 1990-12-12 | — | — | EP | disclosed |