SCHEMBL4427147

SCHEMBL4427147

C=CCn1nc2ccccc2n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.47
NPSR1 Q6W5P4 1/20 0.47
ALDH1A1 P00352 4/20 0.46
HPGD P15428 4/20 0.46
MAPT P10636 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
RAB9A P51151 2/20 0.46
LMNA P02545 1/20 0.46
HSD17B10 Q99714 3/20 0.44
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
PKM P14618 1/20 0.44
L3MBTL1 Q9Y468 3/20 0.43
TSHR P16473 2/20 0.43
TP53 P04637 1/20 0.43
HTT P42858 1/20 0.43
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9942538 0.77 CNR1 (0.36) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL205108 0.77 HPGD (0.38) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL8027203 0.76 KMT2A (0.38) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL11499136 0.74 KDM4E (0.38) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL31497298 0.74 LMNA (0.41) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL2534891 0.73 KDM4E (0.42) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL628393 0.72 CASP3 (0.53) ALDH1A1MAPTSMN1; SMN2RAB9ALMNA
SCHEMBL13817406 0.72 KDM4E (0.46) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL15339460 0.71 PYCR1 (0.38) KDM4ENPSR1ALDH1A1HPGDMAPT
SCHEMBL23523865 0.71 SMN1; SMN2 (0.51) KDM4EALDH1A1MAPTSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10840397-B2 Highly-fluorescent and photo-stable chromophores for wavelength conversion NITTO DENKO CORPORATION (JP) 2020-11-17 US disclosed
US-10461201-B2 Highly-fluorescent and photo-stable chromophores for wavelength conversion NITTO DENKO CORPORATION (JP) 2019-10-29 US disclosed
US-10254567-B2 UV-absorbing vinylic monomers and uses thereof NOVARTIS AG (CH) 2019-04-09 US disclosed
US-20180248053-A1 HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION NITTO DENKO CORP (JP) 2018-08-30 US disclosed
US-9960294-B2 Highly fluorescent and photo-stable chromophores for wavelength conversion NITTO DENKO CORPORATION (JP) 2018-05-01 US disclosed
EP-2941474-B1 HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION NITTO DENKO CORP (JP) 2018-02-28 EP disclosed
US-20170242275-A1 UV-ABSORBING VINYLIC MONOMERS AND USES THEREOF ALCON INC. (CH) 2017-08-24 US disclosed
US-20150340519-A1 HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION NITTO DENKO CORPORATION (JP) 2015-11-26 US disclosed
EP-2941474-A2 HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION Nitto Denko Corporation (JP) 2015-11-11 EP disclosed
US-9184390-B2 Polymers with tunable band gaps for photonic and electronic applications THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2015-11-10 US disclosed
US-4467066-A DIENE-VINYLARENE STAR POLYMER, POLYDIENE, VINYLARENE BLENDS SHELL OIL COMPANY (US) 1984-08-21 US disclosed
US-4425459-A High impact poly(p-methylstyrene) SHELL OIL COMPANY (US) 1984-01-10 US disclosed
EP-0021488-B1 IMPROVED IMPACT POLYMERS AND THEIR PREPARATION SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1983-07-20 EP disclosed
US-4309515-A FREE RADICAL POLYMERIZATION OF VINYL AROMATIC MONOMER IN SOLUTION OF POLYBUTADIENE SHELL OIL COMPANY (US) 1982-01-05 US disclosed
US-4294937-A BULK POLYMERIZED POLYSTYRENE IN THE PRESENCE OF POLYBUTADIENE ELASTOMER AND A BUTADIENE-STYRENE BLOCK POLYMER SHELL OIL COMPANY (US) 1981-10-13 US disclosed
US-4267283-A MADE FROM STYRENE-BUTADIENE BLOCK COPOLYMERS BULK POLYMERIZED WITH STYRENE MONOMER SHELL OIL COMPANY (US) 1981-05-12 US disclosed
EP-0021488-A1 Improved impact polymers and their preparation SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1981-01-07 EP disclosed
US-4240822-A HERBICIDES AMERICAN CYANAMID COMPANY (US) 1980-12-23 US disclosed
US-4086242-A HERBICIDES AMERICAN CYANAMID COMPANY (US) 1978-04-25 US disclosed
US-4026969-A POLYBUTADIENE, POLYISOPRENE, MONOVINYL AROMATIC GRAFT POLYMER SHELL OIL COMPANY (US) 1977-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170242275-A1 UV-ABSORBING VINYLIC MONOMERS AND USES THEREOF UACA, VCL, CRYZ KDM4E 906/4885NPSR1 4594/4885ALDH1A1 646/4885
US-10254567-B2 UV-absorbing vinylic monomers and uses thereof UACA, VCL, CRYZ KDM4E 906/4885NPSR1 4594/4885ALDH1A1 646/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.