Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 3/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081841 | 1.00 | PDPK1 (0.46) | PDPK1PIM1MEN1KMT2AAKT2 | |
| SCHEMBL7082906 | 0.93 | PDPK1 (0.47) | PDPK1MEN1KMT2AAKT2AKT1 | |
| SCHEMBL7082903 | 0.93 | PDPK1 (0.47) | PDPK1MEN1KMT2AAKT2AKT1 | |
| SCHEMBL7086761 | 0.92 | PDPK1 (0.45) | PDPK1AKT2AKT1GSK3BTLK2 | |
| SCHEMBL7086762 | 0.92 | PDPK1 (0.45) | PDPK1AKT2AKT1GSK3BTLK2 | |
| SCHEMBL29643001 | 0.92 | PDPK1 (0.45) | PDPK1AKT2AKT1GSK3BTLK2 | |
| SCHEMBL7087542 | 0.90 | PDPK1 (0.46) | PDPK1KMT2AAKT2AKT1GSK3B | |
| SCHEMBL7084766 | 0.90 | PDPK1 (0.48) | PDPK1MEN1KMT2AAKT2AKT1 | |
| SCHEMBL7084763 | 0.90 | PDPK1 (0.48) | PDPK1MEN1KMT2AAKT2AKT1 | |
| SCHEMBL7087545 | 0.90 | PDPK1 (0.46) | PDPK1KMT2AAKT2AKT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |