Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28838176 | 0.98 | KMT2A (0.56) | KMT2ATDP1L3MBTL1RAB9ANPC1 | |
| SCHEMBL7082383 | 0.93 | TDP1 (0.55) | KMT2ATDP1RAB9ANPC1MAPT | |
| SCHEMBL10404840 | 0.84 | LMNA (0.65) | KMT2ATDP1RAB9AMAPTALDH1A1 | |
| SCHEMBL28356759 | 0.83 | PDE4B (0.55) | RAB9ANPC1MAPTALDH1A1HTT | |
| Water SCHEMBL28445354 | 0.83 | KMT2A (0.58) | KMT2ATDP1L3MBTL1RAB9ANPC1 | |
| Water SCHEMBL29065628 | 0.82 | LMNA (0.63) | KMT2ATDP1RAB9AMAPTALDH1A1 | |
| SCHEMBL64626 | 0.81 | TDP1 (0.70) | KMT2ATDP1RAB9ANPC1MAPT | |
| SCHEMBL28646948 | 0.80 | TDP1 (0.53) | KMT2ATDP1L3MBTL1RAB9ANPC1 | |
| SCHEMBL10634048 | 0.79 | TDP1 (0.67) | KMT2ATDP1RAB9ANPC1MAPT | |
| SCHEMBL6554993 | 0.77 | LMNA (0.74) | KMT2ATDP1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111587240-B | Intermediate of optically active piperidine derivative and process for producing the same | 怡诺安有限公司 | 2023-09-01 | — | — | CN | claimed |
| CN-115010652-A | Synthesis process of piperidine derivative intermediate | 苏州诚和医药化学有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-111587240-A | Intermediate of optically active piperidine derivative and process for producing the same | 怡诺安有限公司 | 2020-08-25 | — | — | CN | claimed |
| CN-112236138-B | Crystal forms and methods of making the same | 赛诺维信制药公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-115087652-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-111587240-B | Intermediate of optically active piperidine derivative and process for producing the same | 怡诺安有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111343990-B | Benzodiazepine-2-one and benzodiazepine-2-one derivatives | 英安塔制药有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-115884971-A | Substituted piperidine compounds and uses thereof | 卫材R&D管理有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-109970614-B | Compounds as TRKA kinase inhibitors and uses thereof | 阵列生物制药公司（US） | 2023-01-13 | — | — | CN | disclosed |
| CN-115087652-A | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-115010652-A | Synthesis process of piperidine derivative intermediate | 苏州诚和医药化学有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-107857755-B | N-pyrrolidinyl, N' -pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TRKA kinase inhibitors | 阵列生物制药公司 | 2020-10-27 | — | — | CN | disclosed |
| CN-111587240-A | Intermediate of optically active piperidine derivative and process for producing the same | 怡诺安有限公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-111343990-A | Process for resolving benzodiazepine-2-one and benzazepine-2-one derivatives | 英安塔制药有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-101959513-A | Novel pharmaceutical composition | GLAXO GROUP LTD | 2011-01-26 | — | — | CN | disclosed |
| CN-101641099-A | Pharmaceutical composition comprising 3, 5-diamino-6- (2, 3-dichlorophenyl) -1, 2, 4-triazine or R (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethylpyrimidine and NK1 | GLAXO GROUP LTD GB | 2010-02-03 | — | — | CN | disclosed |
| CN-101641102-A | Pharmaceutical compositions comprising NK1 receptor antagonists and sodium channel blockers | GLAXO GROUP LTD GB | 2010-02-03 | — | — | CN | disclosed |
| EP-1323713-A1 | 5-PHENYLBENZYLAMINE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND INTERMEDIATES FOR THEIR SYNTHESIS | TANABE SEIYAKU CO., LTD. (JP) | 2003-07-02 | — | — | EP | disclosed |
| CN-1061041-C | Piperidine derivatives | GLAXO GROUP LTD (GB) | 2001-01-24 | — | — | CN | disclosed |
| CN-1135218-A | Piperidine derivatives | GLAXO GROUP LTD (GB) | 1996-11-06 | — | — | CN | disclosed |