Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082450 | 1.00 | RET (0.38) | RETPDPK1IDO1TDO2RXFP1 | |
| SCHEMBL6319480 | 0.90 | IDO1 (0.47) | IDO1TDO2RXFP1L3MBTL1CYP19A1 | |
| SCHEMBL6319476 | 0.90 | IDO1 (0.47) | IDO1TDO2RXFP1L3MBTL1CYP19A1 | |
| SCHEMBL7089162 | 0.87 | NPC1 (0.38) | RETPDPK1IDO1TDO2L3MBTL1 | |
| SCHEMBL7089165 | 0.87 | NPC1 (0.38) | RETPDPK1IDO1TDO2L3MBTL1 | |
| SCHEMBL7087999 | 0.85 | MEN1 (0.43) | PDPK1IDO1TDO2RXFP1L3MBTL1 | |
| SCHEMBL7088005 | 0.85 | MEN1 (0.43) | PDPK1IDO1TDO2RXFP1L3MBTL1 | |
| SCHEMBL6319000 | 0.84 | IDO1 (0.47) | IDO1TDO2RXFP1L3MBTL1CYP19A1 | |
| SCHEMBL6318992 | 0.84 | IDO1 (0.47) | IDO1TDO2RXFP1L3MBTL1CYP19A1 | |
| SCHEMBL6319433 | 0.83 | IDO1 (0.47) | IDO1TDO2RXFP1L3MBTL1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| EP-1071665-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052869-A1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-21 | — | — | WO | disclosed |