Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312160 | 0.82 | CHEK1 (0.46) | CHEK1LIMK1DYRK1ACLK4KDM4E | |
| SCHEMBL5045177 | 0.71 | — | — | |
| SCHEMBL14976996 | 0.69 | CHEK1 (0.51) | CHEK1LIMK1DYRK1ACLK4KDM4E | |
| SCHEMBL30746925 | 0.69 | CHEK1 (0.60) | CHEK1LIMK1DYRK1ACLK4KDM4E | |
| SCHEMBL22616303 | 0.67 | — | — | |
| SCHEMBL15401844 | 0.67 | — | — | |
| SCHEMBL269609 | 0.67 | CHEK1 (0.62) | CHEK1LIMK1DYRK1ACLK4KDM4E | |
| SCHEMBL7331691 | 0.67 | CHEK1 (0.49) | CHEK1LIMK1DYRK1ACLK4KDM4E | |
| SCHEMBL1743494 | 0.66 | MET (0.51) | DYRK1AMET | |
| SCHEMBL11403967 | 0.66 | CHEK1 (0.73) | CHEK1LIMK1DYRK1ACLK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003070244-A1 | ANTAGONIST OF MELANIN CONCENTRATING HORMONE AND THEIR USES | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | claimed |
| WO-2003070244-A1 | ANTAGONIST OF MELANIN CONCENTRATING HORMONE AND THEIR USES | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | disclosed |