Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.49 |
| ▸ | ALB | P02768 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | POLG | P54098 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087937 | 0.94 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL7082705 | 0.77 | LMNA (0.48) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL31206610 | 0.75 | LMNA (0.51) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL22941496 | 0.75 | LMNA (0.51) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL29884375 | 0.75 | LMNA (0.51) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL8093647 | 0.75 | LMNA (0.57) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL7084222 | 0.74 | LMNA (0.48) | LMNAPDE3ACACNA1FALBMAPT | |
| Calcium SCHEMBL31206840 | 0.74 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| Magnesium SCHEMBL31206645 | 0.74 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT | |
| SCHEMBL31206709 | 0.74 | LMNA (0.50) | LMNAPDE3ACACNA1FALBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324997-A2 | DIOXOLANE ANALOGS FOR IMPROVED INTER-CELLULAR DELIVERY | Shire Biochem Inc. (CA) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030922-A2 | DIOXOLANE ANALOGS FOR IMPROVED INTER-CELLULAR DELIVERY | SHIRE BIOCHEM INC. (CA) | 2002-04-18 | — | — | WO | disclosed |