Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.32 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140544 | 0.93 | NR1I2 (0.37) | NR1I2APPHSD11B1HSD17B2HMGCR | |
| SCHEMBL7079256 | 0.87 | NR1I2 (0.48) | NR1I2MAPTHSD11B1HSD17B2HMGCR | |
| SCHEMBL9358093 | 0.78 | HMGCR (0.48) | NR1I2GSTA1GSTP1HMGCR | |
| SCHEMBL9357630 | 0.78 | NR1I2 (0.43) | NR1I2 | |
| SCHEMBL7086714 | 0.77 | HMGCR (0.42) | HSD11B1HSD17B2HMGCR | |
| SCHEMBL7084485 | 0.76 | HMGCR (0.48) | NR1I2GSTA1GSTP1HMGCR | |
| SCHEMBL7083305 | 0.71 | GAA (0.38) | TP53MAPTSMN1; SMN2CYP3A4HSD11B1 | |
| SCHEMBL9358332 | 0.71 | HMGCR (0.50) | NR1I2HMGCR | |
| SCHEMBL9362475 | 0.69 | NR1I2 (0.45) | NR1I2HMGCR | |
| SCHEMBL7085289 | 0.68 | HMGCR (0.50) | NR1I2HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0418064-B1 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR SA (CH) | 1994-12-14 | — | — | EP | disclosed |
| EP-0418064-A2 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR S.A. (CH) | 1991-03-20 | — | — | EP | disclosed |