Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.32 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.32 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.31 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358093 | 0.98 | HMGCR (0.48) | HMGCRNR1I2NR5A2NR5A1GSTA1 | |
| SCHEMBL7085289 | 0.93 | HMGCR (0.50) | HMGCRNR1I2EGFR | |
| SCHEMBL9358332 | 0.91 | HMGCR (0.50) | HMGCRNR1I2 | |
| SCHEMBL7080881 | 0.86 | HMGCR (0.62) | HMGCRNR1I2EGFR | |
| SCHEMBL9358266 | 0.86 | HMGCR (0.43) | HMGCRNR1I2GSTA1GSTP1 | |
| SCHEMBL9358213 | 0.79 | HMGCR (0.45) | HMGCRNR1I2 | |
| SCHEMBL7083231 | 0.79 | HMGCR (0.49) | HMGCRNR1I2NR5A2NR5A1GSTA1 | |
| SCHEMBL7083307 | 0.79 | HMGCR (0.76) | HMGCRNR1I2NR5A2NR5A1EGFR | |
| SCHEMBL9358094 | 0.77 | HMGCR (0.62) | HMGCRNR1I2EGFR | |
| SCHEMBL9358659 | 0.76 | HMGCR (0.37) | HMGCRNR1I2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0418064-B1 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR SA (CH) | 1994-12-14 | — | — | EP | disclosed |
| US-5204336-A | Anticholestrol agents | SYMPHAR S.A. (CH) | 1993-04-20 | — | — | US | disclosed |
| EP-0418064-A2 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR S.A. (CH) | 1991-03-20 | — | — | EP | disclosed |