Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 9/20 | 0.42 |
| ▸ | CDK1 | P06493 | 5/20 | 0.42 |
| ▸ | CDK4 | P11802 | 4/20 | 0.42 |
| ▸ | CCND1 | P24385 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL704772 | 0.93 | CDK2 (0.44) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL31448368 | 0.93 | CDK2 (0.44) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL2680449 | 0.92 | MAPK14 (0.43) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL703570 | 0.91 | MAPK14 (0.42) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL705987 | 0.90 | MAPK14 (0.41) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL703045 | 0.89 | MAPK14 (0.51) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL2680427 | 0.89 | MAPK14 (0.41) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL702868 | 0.87 | MAPK14 (0.46) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL698984 | 0.87 | MAPK14 (0.43) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL708901 | 0.86 | MAPK14 (0.43) | MAPK14CDK2CDK1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421864-B1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-08-06 | — | — | EP | disclosed |
| EP-2421864-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122272-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-10-28 | — | — | WO | disclosed |