Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 13/20 | 0.41 |
| ▸ | CDK1 | P06493 | 10/20 | 0.41 |
| ▸ | CDK4 | P11802 | 9/20 | 0.41 |
| ▸ | CCND1 | P24385 | 9/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CASK | O14936 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | CDK14 | O94921 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MAK | P20794 | 1/20 | 0.37 |
| ▸ | CDK11B | P21127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708407 | 0.92 | MAPK14 (0.43) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL704772 | 0.91 | CDK2 (0.44) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL31448368 | 0.91 | CDK2 (0.44) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL703570 | 0.89 | MAPK14 (0.42) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL705987 | 0.88 | MAPK14 (0.41) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL703045 | 0.88 | MAPK14 (0.51) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL15911533 | 0.88 | MAPK14 (0.42) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL2680427 | 0.88 | MAPK14 (0.41) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL702868 | 0.86 | MAPK14 (0.46) | MAPK14CDK2CDK1CDK4CCND1 | |
| SCHEMBL698984 | 0.86 | MAPK14 (0.43) | MAPK14CDK2CDK1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461175-B2 | 1-pyrazolo[4,3-c]isoquinoline derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2013-06-11 | — | — | US | disclosed |
| US-20120115898-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115898-A1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | CBR3, CYP4F3, HCCS | MAPK14 4041/4885CDK2 968/4885CDK1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.