Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 2/20 | 0.34 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.33 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.33 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080094 | 0.93 | HMGCR (0.51) | HMGCRNR1I2MEN1GAAKMT2A | |
| SCHEMBL6942208 | 0.89 | HMGCR (0.63) | HMGCRNR1I2MEN1GAAKMT2A | |
| SCHEMBL7083307 | 0.80 | HMGCR (0.76) | HMGCRNR1I2MEN1GAAKMT2A | |
| SCHEMBL7083575 | 0.79 | HMGCR (0.63) | HMGCRNR1I2MEN1GAAKMT2A | |
| SCHEMBL9358093 | 0.79 | HMGCR (0.48) | HMGCRNR1I2GSTA1GSTP1NR5A2 | |
| SCHEMBL7084485 | 0.79 | HMGCR (0.48) | HMGCRNR1I2GSTA1GSTP1NR5A2 | |
| SCHEMBL9357630 | 0.79 | NR1I2 (0.43) | NR1I2MEN1KMT2A | |
| SCHEMBL9358182 | 0.78 | MEN1 (0.40) | HMGCRNR1I2MEN1GAAKMT2A | |
| SCHEMBL7083360 | 0.78 | NR1I2 (0.45) | HMGCRNR1I2MEN1KMT2AGSTA1 | |
| SCHEMBL7083282 | 0.77 | HMGCR (0.83) | HMGCRNR1I2MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0418064-B1 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR SA (CH) | 1994-12-14 | — | — | EP | disclosed |
| EP-0418064-A2 | Naphthalene and tetrahydronaphthalene gem-diphosphonate derivatives | SYMPHAR S.A. (CH) | 1991-03-20 | — | — | EP | disclosed |