Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089708 | 0.88 | MAPT (0.63) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7085144 | 0.88 | MAPT (0.69) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7090097 | 0.88 | MAPT (0.66) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7089964 | 0.87 | MAPT (0.61) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7088467 | 0.87 | MAPT (0.47) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL6520241 | 0.83 | MAPT (0.56) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL6515298 | 0.82 | MAPT (0.55) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL6512804 | 0.82 | MAPT (0.55) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL7088027 | 0.81 | MAPT (0.69) | MAPTSMN1; SMN2HTTLMNATP53 | |
| SCHEMBL6512173 | 0.81 | MAPT (0.53) | MAPTSMN1; SMN2HTTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |