Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092628 | 0.92 | MAPT (0.67) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL7089964 | 0.88 | MAPT (0.61) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL7084609 | 0.88 | MAPT (0.61) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL7083892 | 0.88 | MAPT (0.67) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL7093571 | 0.88 | MAPT (0.53) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL7085144 | 0.83 | MAPT (0.69) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL7089593 | 0.83 | MAPT (0.69) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL6512092 | 0.83 | MAPT (0.60) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL6515541 | 0.82 | MAPT (0.59) | MAPTTP53SMN1; SMN2HTTLMNA | |
| SCHEMBL6511488 | 0.81 | MAPT (0.58) | MAPTTP53SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347959-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |