Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299360 | 1.00 | TACR1 (0.56) | TACR1GAAMAPTLMNAKMT2A | |
| SCHEMBL6953117 | 0.82 | MEN1 (0.54) | GAAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6307079 | 0.82 | MAPT (0.54) | TACR1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL7086322 | 0.82 | MAPT (0.54) | TACR1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL6952606 | 0.80 | TACR1 (0.67) | TACR1GAAMAPTLMNA | |
| SCHEMBL6301682 | 0.80 | HTR2A (0.58) | TACR1GAAMAPTLMNAKMT2A | |
| Hydrochloric Acid SCHEMBL7834943 | 0.79 | GAA (0.58) | TACR1GAAMAPTLMNAKMT2A | |
| Hydrochloric Acid SCHEMBL7837180 | 0.79 | GAA (0.58) | TACR1GAAMAPTLMNAKMT2A | |
| SCHEMBL7090474 | 0.79 | MAPT (0.67) | TACR1GAAMAPTLMNAKMT2A | |
| SCHEMBL6307157 | 0.79 | MAPT (0.67) | TACR1GAAMAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005454-A4 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6358994-B1 | 2-((2-PHENOXY)ACETYL)AMINO-3-(1H-INDOL-3-YL)-1-(N-2 -METHOXYBENZYL)ACETYLAMINO)PROPANE | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| US-6339094-B1 | FOR THERAPY OF CONDITION ASSOCIATED WITH AN EXCESS OF TACHYKININS SUCH AS MIGRANE HEADACHES | ELI LILLY AND COMPANY | 2002-01-15 | — | — | US | disclosed |
| EP-0693489-B1 | Heterocyclic tachykinin receptor antagonist | LILLY CO ELI (US) | 2001-09-12 | — | — | EP | disclosed |
| CN-1067067-C | Heterocyclic tachykinin receptor antagonists | LILLY CO ELI (US) | 2001-06-13 | — | — | CN | disclosed |
| EP-1003723-A4 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2000-11-02 | — | — | EP | disclosed |
| EP-0912178-A4 | METHODS OF TREATING HYPERTENSION | LILLY CO ELI (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-0932406-A4 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | LILLY CO ELI (US) | 2000-07-05 | — | — | EP | disclosed |
| EP-1005454-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-06-07 | — | — | EP | disclosed |
| EP-1003723-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1996041633-A1 | METHODS OF TREATING COLD AND ALLERGIC RHINITIS | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | WO | disclosed |
| EP-0747049-A1 | Use of tachykinin antagonists in combination with serotonin agonists or serotonin reuptake inhibitors for the manufacture of a medicament for the treatment of allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747055-A2 | Use of tachykinin receptors antagonists for the treatment of cold and allergic rhinitis | ELI LILLY AND COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1996029074-A1 | METHODS OF TREATING OR PREVENTING PAIN OR NOCICEPTION | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| WO-1996024353-A1 | METHODS OF TREATING OR PREVENTING PSYCHIATRIC DISORDERS | ELI LILLY AND COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5530009-A | TREATING ASTHMA | ELI LILLY AND COMPANY (US) | 1996-06-25 | — | — | US | disclosed |
| EP-0710479-A1 | Use of a serotonin agonist in combination with a tachykinin receptor antagonist for the manufacture of a medicament for the treatment or prevention of migraine | ELI LILLY AND COMPANY (US) | 1996-05-08 | — | — | EP | disclosed |
| WO-1996011000-A1 | METHODS OF TREATING MIGRAINE | ELI LILLY AND COMPANY (US) | 1996-04-18 | — | — | WO | disclosed |
| WO-1996001819-A1 | HETEROCYCLIC TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-01-25 | — | — | WO | disclosed |
| EP-0693489-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-24 | — | — | EP | disclosed |