Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 7/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299360 | 0.82 | TACR1 (0.56) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL7084628 | 0.82 | TACR1 (0.56) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL6950191 | 0.79 | HPGD (0.49) | MEN1KMT2AITGA4ITGB7ALDH1A1 | |
| SCHEMBL6950194 | 0.74 | TACR1 (0.58) | — | |
| SCHEMBL9353878 | 0.74 | BCHE (0.53) | MEN1KMT2ABCHEITGA4ITGB7 | |
| SCHEMBL5216965 | 0.72 | BCHE (0.69) | MEN1KMT2ABCHEBACE1ITGA4 | |
| SCHEMBL8883322 | 0.72 | KDM4E (0.70) | MEN1KMT2ABCHEALDH1A1KDM4E | |
| SCHEMBL6555107 | 0.72 | MEN1 (0.68) | MEN1KMT2ABCHEALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8615245 | 0.71 | MEN1 (0.66) | MEN1KMT2ABCHEALDH1A1KDM4E | |
| SCHEMBL5695121 | 0.70 | ALDH1A1 (0.79) | MEN1KMT2ABCHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699665-B1 | Imidazoline derivatives, their preparation and their use as tachykinin receptor antagonists | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6175013-B1 | 1-(2-METHOXYBENZYL)-2-((4-PHENYL-1-PIPERAZINYL)METHYL)-4-(1H -INDOL-3-YLMETHYL)-2-IMIDAZOLINE, FOR EXAMPLE; ADMINSTERING TO TREAT ANXIETY, DEPRESSION, PSYCHOSIS, AND SCHIZOPHRENIA | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| EP-0699665-A1 | Imidazoline derivatives, their preparation and their use as tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-06 | — | — | EP | disclosed |