Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.48 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940429 | 1.00 | MAPT (0.51) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4942276 | 0.86 | NPSR1 (0.53) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4943227 | 0.86 | RORC (0.54) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL5735506 | 0.86 | MAPT (0.48) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4939781 | 0.86 | MAPT (0.48) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL5475200 | 0.84 | NPY2R (0.45) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4944158 | 0.84 | NPY2R (0.45) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4944161 | 0.84 | NPY2R (0.45) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4945448 | 0.83 | NPSR1 (0.50) | MAPTLMNANPSR1ALDH1A1HPGD | |
| SCHEMBL4944102 | 0.82 | MAPT (0.50) | MAPTLMNANPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |