Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 4/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711118 | 0.89 | CXCR4 (0.43) | CXCR4CHRM2CARM1PRMT6METAP2 | |
| SCHEMBL5517968 | 0.84 | CXCR4 (0.43) | CXCR4CHRM2KCNH2CARM1PRMT6 | |
| SCHEMBL5518343 | 0.82 | CARM1 (0.42) | KCNH2CARM1PRMT6SLC6A9 | |
| SCHEMBL708523 | 0.82 | POLB (0.44) | MCHR1METAP2 | |
| SCHEMBL713075 | 0.77 | CXCR4 (0.50) | CXCR4CHRM2MCHR1CARM1PRMT6 | |
| SCHEMBL5505044 | 0.77 | CXCR4 (0.43) | CXCR4CHRM2CARM1PRMT6 | |
| SCHEMBL710944 | 0.75 | CARM1 (0.50) | CXCR4CHRM2MCHR1CARM1PRMT6 | |
| SCHEMBL3770856 | 0.75 | CXCR4 (0.51) | CXCR4CHRM2MCHR1CARM1PRMT6 | |
| SCHEMBL5512689 | 0.75 | DPP7 (0.43) | KCNH2CARM1PRMT6LMNA | |
| SCHEMBL3770111 | 0.75 | CXCR4 (0.49) | CXCR4CHRM2MCHR1CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |
| US-8124639-B2 | Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors | PFIZER INC. (US) | 2012-02-28 | — | — | US | disclosed |