Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711117 | 0.90 | CYP3A4 (0.46) | POLBRXFP1MCHR1P2RX7METAP2 | |
| SCHEMBL5517965 | 0.85 | MCHR1 (0.46) | POLBRXFP1MCHR1P2RX7METAP2 | |
| SCHEMBL708524 | 0.82 | CXCR4 (0.42) | MCHR1METAP2 | |
| SCHEMBL713074 | 0.80 | P2RX7 (0.57) | POLBRXFP1MCHR1P2RX7F2 | |
| SCHEMBL5505041 | 0.79 | POLB (0.52) | POLBRXFP1P2RX7F2MC4R | |
| SCHEMBL710943 | 0.78 | P2RX7 (0.53) | POLBRXFP1MCHR1P2RX7F2 | |
| SCHEMBL3770854 | 0.78 | MC4R (0.61) | POLBRXFP1MCHR1P2RX7F2 | |
| SCHEMBL3770109 | 0.77 | RXFP1 (0.55) | POLBRXFP1MCHR1P2RX7F2 | |
| SCHEMBL3777749 | 0.76 | MC4R (0.56) | POLBRXFP1MCHR1P2RX7F2 | |
| SCHEMBL710581 | 0.75 | MCHR1 (0.48) | POLBRXFP1MCHR1P2RX7F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |
| US-8124639-B2 | Bicyclic [3.1.0] heteroaryl amides as type 1 glycine transport inhibitors | PFIZER INC. (US) | 2012-02-28 | — | — | US | disclosed |