Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13866807 | 0.78 | PLAU (0.52) | PLAUANPEPIDO1PSEN1PSEN2 | |
| SCHEMBL15043375 | 0.78 | PLAU (0.52) | PLAUANPEPIDO1PSEN1PSEN2 | |
| SCHEMBL5069739 | 0.78 | PLAU (0.52) | PLAUANPEPIDO1PSEN1PSEN2 | |
| SCHEMBL6108075 | 0.78 | PLAU (0.52) | PLAUANPEPIDO1PSEN1PSEN2 | |
| SCHEMBL2343768 | 0.77 | IDO1 (0.46) | PLAUANPEPIDO1PSEN1PSEN2 | |
| SCHEMBL14990041 | 0.72 | PLAU (0.44) | PLAUIDO1PSEN1PSEN2APH1B | |
| SCHEMBL29949831 | 0.72 | PLAU (0.44) | PLAUIDO1PSEN1PSEN2APH1B | |
| SCHEMBL14760073 | 0.72 | PLAU (0.44) | PLAUIDO1PSEN1PSEN2APH1B | |
| SCHEMBL29365759 | 0.71 | PLAU (0.68) | PLAUANPEPIDO1SIGMAR1 | |
| SCHEMBL6941 | 0.71 | PLAU (0.68) | PLAUANPEPIDO1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010694-B1 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | SERVIER LAB (FR) | 2003-08-06 | — | — | EP | disclosed |
| EP-1010694-A2 | Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |