Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27564857 | 1.00 | ADORA2A (0.47) | ADORA2AKDM4EMEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL7088885 | 0.99 | ADORA2A (0.47) | ADORA2AKDM4EMEN1MAPTKMT2A | |
| SCHEMBL13729103 | 0.77 | APP (0.54) | ADORA2AMAPTADORA3CDK1ADORA2B | |
| SCHEMBL7658491 | 0.75 | KDM4E (0.44) | KDM4EMEN1MAPTKMT2ACDK1 | |
| SCHEMBL27763565 | 0.74 | KDM4E (0.43) | KDM4EMEN1MAPTKMT2ACDK1 | |
| SCHEMBL27763566 | 0.74 | KDM4E (0.43) | KDM4EMEN1MAPTKMT2ACDK1 | |
| SCHEMBL9792866 | 0.74 | APP (0.57) | ADORA2AKMT2AADORA3ADORA2BADORA1 | |
| SCHEMBL24669720 | 0.73 | CDK2 (0.65) | CDK1CDK5CDK2CCNE2CCNE1 | |
| SCHEMBL27763562 | 0.73 | KDM4E (0.42) | KDM4EMEN1MAPTKMT2ACDK1 | |
| SCHEMBL17815577 | 0.72 | ADORA1 (0.55) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090022-B1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-6495528-B1 | ANTIINFLAMMATORY AGENTS; INHIBITING LEUKOCYTE RECRUITMENT AND ACTIVATION; AGONISTS OF ADENOSINE 2A RECEPTOR | SMITHKLINE BEECHAM CORPORATION | 2002-12-17 | — | — | US | disclosed |
| CN-1313861-A | 2-(purin-9-YL)-tetrahydrofuran-3,4-diolderivatives | GLAXO GROUP LTD (GB) | 2001-09-19 | — | — | CN | disclosed |