Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086337 | 1.00 | NAMPT (0.44) | NAMPTALDH1A1L3MBTL1PDPK1AKT2 | |
| SCHEMBL7086762 | 0.89 | PDPK1 (0.45) | PDPK1AKT2 | |
| SCHEMBL29643001 | 0.89 | PDPK1 (0.45) | PDPK1AKT2 | |
| SCHEMBL7086761 | 0.89 | PDPK1 (0.45) | PDPK1AKT2 | |
| SCHEMBL7086305 | 0.88 | BACE1 (0.45) | PDPK1AKT2 | |
| SCHEMBL7086310 | 0.88 | BACE1 (0.45) | PDPK1AKT2 | |
| SCHEMBL7239292 | 0.86 | PDPK1 (0.43) | NAMPTALDH1A1PDPK1AKT2TGM2 | |
| SCHEMBL7239288 | 0.86 | PDPK1 (0.43) | NAMPTALDH1A1PDPK1AKT2TGM2 | |
| SCHEMBL7087980 | 0.85 | PDPK1 (0.50) | ALDH1A1PDPK1AKT2SMN1; SMN2LMNA | |
| SCHEMBL7087977 | 0.85 | PDPK1 (0.50) | ALDH1A1PDPK1AKT2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |