Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 3/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086310 | 1.00 | BACE1 (0.45) | BACE1PDPK1JAK2TYK2TLK2 | |
| SCHEMBL7086762 | 0.92 | PDPK1 (0.45) | PDPK1TLK2AKT2KDRRET | |
| SCHEMBL29643001 | 0.92 | PDPK1 (0.45) | PDPK1TLK2AKT2KDRRET | |
| SCHEMBL7086761 | 0.92 | PDPK1 (0.45) | PDPK1TLK2AKT2KDRRET | |
| SCHEMBL13247747 | 0.91 | BACE1 (0.50) | BACE1PDPK1JAK2TYK2POLB | |
| SCHEMBL7082903 | 0.91 | PDPK1 (0.47) | PDPK1TLK2AKT2MAPTRET | |
| SCHEMBL7082906 | 0.91 | PDPK1 (0.47) | PDPK1TLK2AKT2MAPTRET | |
| SCHEMBL7086341 | 0.88 | NAMPT (0.44) | PDPK1AKT2 | |
| SCHEMBL7086337 | 0.88 | NAMPT (0.44) | PDPK1AKT2 | |
| SCHEMBL7089576 | 0.87 | PDPK1 (0.45) | PDPK1TLK2AKT2KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071665-B1 | SUBSTITUTED INDOLINONES HAVING AN INHIBITING EFFECT ON KINASES AND CYCLINE/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |