Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 13/20 | 0.85 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704691 | 0.92 | HMGCR (1.00) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7086181 | 0.84 | HMGCR (0.85) | HMGCR | |
| SCHEMBL9723401 | 0.82 | HMGCR (0.81) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7526269 | 0.82 | HMGCR (0.56) | HMGCRCYP1A2CYP2C9CYP2C19GAA | |
| SCHEMBL7083916 | 0.81 | HMGCR (0.80) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7134552 | 0.79 | HMGCR (0.76) | HMGCRNR1I2CYP1A2GAAMEN1 | |
| SCHEMBL15705739 | 0.78 | HMGCR (0.52) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7084466 | 0.77 | HMGCR (0.74) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9723334 | 0.76 | HMGCR (0.71) | HMGCRNR1I2CYP1A2CYP2C9CYP2C19 | |
| Apomine SCHEMBL1648488 | 0.75 | HMGCR (1.00) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | claimed |
| US-6127350-A | FOR TREATMENT AND PREVENTION OF RAS ONCOGENE DEPENDENT CANCERS AND METASTATIC INVASIONS | SYMPHAR S.A. (SE) | 2000-10-03 | — | — | US | claimed |
| US-5043330-A | Antiinflammatory and hypotensive agents; antihyperlipemia | SYMPHAR S.A. (CH) | 1991-08-27 | — | — | US | claimed |
| US-5128331-A | Gen-diphosphonates | SYMPHAR S.A. (CH) | 1992-07-07 | — | — | US | disclosed |