Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 6/20 | 0.75 |
| ▸ | OXTR | P30559 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942915 | 1.00 | AVPR1A (0.75) | AVPR1AOXTRLMNAAVPR2PDE5A | |
| SCHEMBL7086396 | 0.95 | AVPR1A (0.73) | AVPR1AOXTRLMNAAVPR2PDE5A | |
| SCHEMBL4940423 | 0.95 | AVPR1A (0.73) | AVPR1AOXTRLMNAAVPR2PDE5A | |
| SCHEMBL5759282 | 0.91 | OXTR (0.73) | AVPR1AOXTRAVPR2FFAR2 | |
| SCHEMBL4942676 | 0.91 | OXTR (0.73) | AVPR1AOXTRAVPR2FFAR2 | |
| SCHEMBL4939162 | 0.91 | OXTR (0.73) | AVPR1AOXTRLMNAFFAR2MMP1 | |
| SCHEMBL4944329 | 0.91 | OXTR (0.73) | AVPR1AOXTRLMNAFFAR2MMP1 | |
| SCHEMBL4945222 | 0.89 | AVPR1A (0.73) | AVPR1AOXTRAVPR2FFAR2SLC6A7 | |
| SCHEMBL4945483 | 0.89 | AVPR1A (0.75) | AVPR1AOXTRLMNAAVPR2FFAR2 | |
| SCHEMBL4938918 | 0.88 | OXTR (0.85) | AVPR1AOXTRLMNAAVPR2FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |