Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 5/20 | 0.70 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 4/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942292 | 1.00 | OXTR (0.70) | OXTRAVPR1ALMNATLR2TLR1 | |
| SCHEMBL4942110 | 0.97 | OXTR (0.71) | OXTRAVPR1ALMNATLR2TLR1 | |
| SCHEMBL4939162 | 0.93 | OXTR (0.73) | OXTRAVPR1ALMNAMMP1MMP3 | |
| SCHEMBL4944329 | 0.93 | OXTR (0.73) | OXTRAVPR1ALMNAMMP1MMP3 | |
| SCHEMBL4943696 | 0.89 | OXTR (0.72) | OXTRAVPR1ALMNAMMP1MMP3 | |
| SCHEMBL7086396 | 0.88 | AVPR1A (0.73) | OXTRAVPR1ALMNADRD2DRD3 | |
| SCHEMBL4940423 | 0.88 | AVPR1A (0.73) | OXTRAVPR1ALMNADRD2DRD3 | |
| SCHEMBL7088615 | 0.87 | OXTR (0.70) | OXTRAVPR1ALMNATLR2TLR1 | |
| SCHEMBL7164251 | 0.87 | OXTR (0.70) | OXTRAVPR1ALMNAMMP1MMP3 | |
| SCHEMBL4943384 | 0.87 | OXTR (0.70) | OXTRAVPR1ALMNATLR2TLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |