Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 9/20 | 0.63 |
| ▸ | MME | P08473 | 2/20 | 0.54 |
| ▸ | ACE | P12821 | 2/20 | 0.54 |
| ▸ | IL1B | P01584 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 8/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1409094 | 0.90 | CASP1 (0.59) | CASP1MMEACEIL1BLCK | |
| SCHEMBL2219237 | 0.90 | CASP1 (0.59) | CASP1MMEACEIL1BLCK | |
| SCHEMBL10248560 | 0.89 | CASP1 (0.65) | CASP1MMEACEIL1BLCK | |
| SCHEMBL10263501 | 0.89 | CASP1 (0.67) | CASP1MMEACEIL1BLCK | |
| SCHEMBL646584 | 0.89 | CASP1 (0.67) | CASP1MMEACEIL1BLCK | |
| SCHEMBL7087544 | 0.89 | CASP1 (0.67) | CASP1MMEACEIL1BLCK | |
| SCHEMBL644771 | 0.89 | CASP1 (0.67) | CASP1MMEACEIL1BLCK | |
| SCHEMBL14070414 | 0.88 | CASP1 (0.66) | CASP1MMEACEIL1BLCK | |
| SCHEMBL12809925 | 0.85 | CASP1 (0.59) | CASP1MMEACEIL1BLCK | |
| SCHEMBL13776506 | 0.83 | CASP1 (0.71) | CASP1MMEACEIL1BLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030100550-A1 | Carboxamide diazepin derivatives, preparation method, use as medicines, pharmaceutical compositions and use thereof | AVENTIS PHARMA S.A. (FR) | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100550-A1 | Carboxamide diazepin derivatives, preparation method, use as medicines, pharmaceutical compositions and use thereof | HRH4, HRH3, HRH2 | CASP1 2506/4885MME 2031/4885ACE 2615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.