Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.76 |
| ▸ | MMP3 | P08254 | 5/20 | 0.76 |
| ▸ | MMP2 | P08253 | 5/20 | 0.76 |
| ▸ | MMP9 | P14780 | 5/20 | 0.76 |
| ▸ | MMP13 | P45452 | 5/20 | 0.76 |
| ▸ | MMP1 | P03956 | 4/20 | 0.76 |
| ▸ | MMP7 | P09237 | 4/20 | 0.76 |
| ▸ | MMP8 | P22894 | 4/20 | 0.76 |
| ▸ | MMP14 | P50281 | 4/20 | 0.76 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.76 |
| ▸ | MMP15 | P51511 | 1/20 | 0.59 |
| ▸ | MMP16 | P51512 | 1/20 | 0.59 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7247486 | 0.96 | ADAM17 (0.70) | ADAM17MMP3MMP2MMP9MMP13 | |
| Trifluoroacetic Acid SCHEMBL7247348 | 0.89 | ADAM17 (0.73) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL8354979 | 0.87 | ADAM17 (0.82) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL29732231 | 0.86 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6350415 | 0.86 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL1021287 | 0.86 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6350418 | 0.86 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL7067227 | 0.84 | ADAM17 (0.80) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL29528576 | 0.83 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 | |
| SCHEMBL6685571 | 0.83 | ADAM17 (1.00) | ADAM17MMP3MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299379-A2 | LACTAM METALLOPROTEASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-09 | — | — | EP | claimed |
| WO-2002004416-A2 | LACTAM METALLOPROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-17 | — | — | WO | claimed |