SCHEMBL7087345

SCHEMBL7087345

Cc1c(C(=O)N2CCOCC2)c(-c2cccc3ccccc23)cn1-c1cncn1Cc1ccc(Br)cc1

nearest known ligand 0.64

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FNTA P49354 10/20 0.64
FNTB P49356 10/20 0.64
PGGT1B P53609 5/20 0.49
HTR2C P28335 5/20 0.42
CYP3A4 P08684 1/20 0.42
LMNA P02545 1/20 0.42
RECQL P46063 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ALDH1A1 P00352 1/20 0.38
EPAS1 Q99814 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7084214 0.94 FNTA (0.56) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL7087365 0.91 FNTA (0.52) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL7088695 0.85 FNTA (0.50) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL6975071 0.84 FNTA (0.49) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL6982939 0.83 FNTA (0.49) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL6985597 0.82 FNTA (0.48) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL7083087 0.81 FNTA (0.46) FNTAFNTBPGGT1B
SCHEMBL7087481 0.81 FNTA (0.49) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL6982184 0.80 FNTA (0.51) FNTAFNTBPGGT1BHTR2CCYP3A4
SCHEMBL7081052 0.79 FNTA (0.46) FNTAFNTBPGGT1BHTR2CCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1045846-B1 IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LTD (KR) 2003-05-02 EP disclosed
EP-1045846-A1 IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LIMITED (KR) 2000-10-25 EP disclosed
WO-1999028315-A1 IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF LG CHEMICAL LTD. (KR) 1999-06-10 WO disclosed