SCHEMBL7087445

SCHEMBL7087445

COc1ccc(SC#N)cc1SC#N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 10/20 0.43
ALDH1A1 P00352 8/20 0.41
MAPT P10636 8/20 0.41
POLB P06746 1/20 0.41
KDM4E B2RXH2 2/20 0.37
USP2 O75604 1/20 0.37
MEN1 O00255 2/20 0.36
LMNA P02545 2/20 0.36
KMT2A Q03164 2/20 0.36
CYP1A2 P05177 1/20 0.36
GLA P06280 1/20 0.36
CYP3A4 P08684 1/20 0.36
GAA P10253 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
GFER P55789 1/20 0.35
GABRA1 P14867 1/20 0.35
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3408344 0.85 AR (0.46) ARALDH1A1MAPTPOLBMEN1
SCHEMBL10228011 0.76 AR (0.41) ARALDH1A1MAPTPOLBMEN1
SCHEMBL24575343 0.76 AR (0.41) ARALDH1A1MAPTPOLBMEN1
SCHEMBL11098616 0.76 MAOB (0.50) ARALDH1A1MEN1LMNAKMT2A
SCHEMBL6932331 0.76 AR (0.51) ARALDH1A1MAPTPOLBKDM4E
SCHEMBL13002497 0.75 CA12 (0.57) ALDH1A1MAPTKDM4ELMNACYP1A2
SCHEMBL7939412 0.75 ALDH1A1 (0.48) ALDH1A1MAPTMEN1LMNAKMT2A
SCHEMBL7459101 0.75 ALDH1A1 (0.44) ARALDH1A1MAPTPOLBUSP2
SCHEMBL6979134 0.73 MAPT (0.33) ARALDH1A1MAPTPOLBKDM4E
SCHEMBL14492414 0.73 FLT1 (0.41) ALDH1A1MAPTPOLBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177194-B1 4-(3',4'-HETEROCYCLYL BENZOYL) PYRAZOLES AS HERBICIDAL AGENTS BASF AG (DE) 2003-09-17 EP disclosed
US-6589915-B1 The invention relates to cyclohexenone derivatives of benzo-condensed, unsaturated 5-ring nitrogen heterocycles of general formula (I) wherein X represents N or a group C-R3, Y represents O, S, SO, SO2 or NR4 or X-Y represent S BASF AKTIENGESELLSCHAFT (DE) 2003-07-08 US disclosed
US-6541423-B1 Controlling vegatation BASF AKTIENGESELLSCHAFT (DE) 2003-04-01 US disclosed
EP-1177179-A1 BENZOHETERO CYCLYLCYCLO HEXENONES AND THEIR USE AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2002-02-06 EP disclosed
EP-1177194-A1 4-(3',4'-HETEROCYCLYL BENZOYL) PYRAZOLES AS HERBICIDAL AGENTS BASF AKTIENGESELLSCHAFT (DE) 2002-02-06 EP disclosed
WO-2000068228-A1 4-(3',4'-HETEROCYCLYL BENZOYL) PYRAZOLES AS HERBICIDAL AGENTS BASF AKTIENGESELLSCHAFT (DE) 2000-11-16 WO disclosed
WO-2000068210-A1 BENZOHETERO CYCLYLCYCLO HEXENONES AND THEIR USE AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2000-11-16 WO disclosed