Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methysergide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 3/20 | 0.98 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.98 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.98 |
| ▸ | MEN1 | O00255 | 9/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.98 |
| ▸ | HPGD | P15428 | 7/20 | 0.98 |
| ▸ | MAPT | P10636 | 5/20 | 0.98 |
| ▸ | RECQL | P46063 | 3/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.98 |
| ▸ | GLA | P06280 | 2/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.98 |
| ▸ | DRD2 | P14416 | 2/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.98 |
| ▸ | DRD1 | P21728 | 2/20 | 0.98 |
| ▸ | HRH2 | P25021 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methysergide SCHEMBL467884 | 0.99 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL41843 | 0.99 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL467883 | 0.99 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL29359107 | 0.99 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL28086572 | 0.98 | KMT2A (0.98) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methsergide SCHEMBL29601488 | 0.94 | KMT2A (0.91) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL41844 | 0.94 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL29408580 | 0.94 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL21803661 | 0.94 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 | |
| Methysergide SCHEMBL28196309 | 0.94 | KMT2A (1.00) | KMT2AALDH1A1MEN1KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030083485-A1 | Nucleotide sequences coding polypeptide for use the treament of cardiovascular disorders | PFIZER INC. | 2003-05-01 | — | — | US | claimed |
| US-20030083485-A1 | Nucleotide sequences coding polypeptide for use the treament of cardiovascular disorders | PFIZER INC. | 2003-05-01 | — | — | US | disclosed |