Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | LAP3 | P28838 | 2/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989582 | 0.97 | OPRM1 (0.56) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL15435975 | 0.97 | OPRM1 (0.56) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL10398186 | 0.97 | OPRM1 (0.56) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL9656673 | 0.97 | OPRM1 (0.56) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL28515707 | 0.97 | OPRM1 (0.56) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL28620894 | 0.97 | OPRM1 (0.56) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL4953708 | 0.95 | OPRM1 (0.54) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL19577535 | 0.95 | OPRM1 (0.54) | OPRM1SPHK1TP53CYP2D6LMNA | |
| Hydrochloric Acid SCHEMBL27808695 | 0.95 | OPRM1 (0.54) | OPRM1SPHK1TP53CYP2D6LMNA | |
| SCHEMBL4953066 | 0.95 | OPRM1 (0.54) | OPRM1SPHK1TP53CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005454-A4 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2003-01-15 | — | — | EP | disclosed |
| US-6358994-B1 | 2-((2-PHENOXY)ACETYL)AMINO-3-(1H-INDOL-3-YL)-1-(N-2 -METHOXYBENZYL)ACETYLAMINO)PROPANE | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| US-6339094-B1 | FOR THERAPY OF CONDITION ASSOCIATED WITH AN EXCESS OF TACHYKININS SUCH AS MIGRANE HEADACHES | ELI LILLY AND COMPANY | 2002-01-15 | — | — | US | disclosed |
| EP-1003723-A4 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2000-11-02 | — | — | EP | disclosed |
| EP-1005454-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-06-07 | — | — | EP | disclosed |
| EP-1003723-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007677-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |
| WO-1999007681-A1 | 2-ACYLAMINOPROPANAMINES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |
| WO-1997023455-A1 | PROCESSES FOR PREPARING NON-PEPTIDYL TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-07-03 | — | — | WO | disclosed |