Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 11/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085406 | 0.87 | SERPINE1 (0.77) | SERPINE1MAPTNPSR1GAAMAPK1 | |
| SCHEMBL7087924 | 0.86 | SERPINE1 (0.75) | SERPINE1MAPTNPSR1GAACYP2C9 | |
| SCHEMBL7087964 | 0.85 | SERPINE1 (1.00) | SERPINE1MAPTNPSR1GAAMAPK1 | |
| SCHEMBL7084123 | 0.81 | SERPINE1 (0.82) | SERPINE1MAPTNPSR1MAPK1CYP2C9 | |
| SCHEMBL7088169 | 0.81 | SERPINE1 (1.00) | SERPINE1MAPTCYP2C9CYP2C19CYP1A2 | |
| SCHEMBL7084109 | 0.79 | SERPINE1 (0.82) | SERPINE1MAPTNPSR1MAPK1CYP2C9 | |
| SCHEMBL7091396 | 0.79 | SERPINE1 (1.00) | SERPINE1MAPTL3MBTL1LMNA | |
| SCHEMBL7089371 | 0.77 | SERPINE1 (0.72) | SERPINE1MAPTCYP2C9CYP2C19CYP1A2 | |
| SCHEMBL7084175 | 0.77 | SERPINE1 (0.77) | SERPINE1MAPTCYP2C9CYP2C19CYP1A2 | |
| SCHEMBL7084622 | 0.77 | SERPINE1 (1.00) | SERPINE1MAPTL3MBTL1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080060-A1 | SUBSTITUTED PIPERAZINE ANTITHROMBOTIC PAI-1 INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | WO | disclosed |