Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | PRKDC | P78527 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | YWHAG | P61981 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30798758 | 0.79 | HPGD (0.45) | KDM4EHTTMAPTHSD17B10ALOX15 | |
| SCHEMBL29410870 | 0.77 | NPC1 (0.70) | KDM4EMAPTMEN1KMT2AAURKA | |
| SCHEMBL325422 | 0.77 | NPC1 (0.70) | KDM4EMAPTMEN1KMT2AAURKA | |
| SCHEMBL79339 | 0.76 | KDM4E (0.74) | KDM4EHTTMAPTHSD17B10ALOX15 | |
| SCHEMBL3120753 | 0.76 | ALDH1A1 (0.54) | KDM4EHTTMAPTHSD17B10ALOX15 | |
| SCHEMBL23059699 | 0.76 | MAPT (0.56) | KDM4EHTTPRKDCMAPTHSD17B10 | |
| Bromide SCHEMBL6256143 | 0.75 | NPC1 (0.68) | KDM4EMAPTMEN1KMT2AAURKA | |
| SCHEMBL7449213 | 0.75 | AKR1C3 (0.56) | KDM4EHTTPRKDCMAPTHSD17B10 | |
| SCHEMBL6073272 | 0.74 | MAPT (0.47) | KDM4EHTTMAPTHSD17B10ALOX15 | |
| SCHEMBL4992024 | 0.73 | PRKDC (0.73) | KDM4EHTTPRKDCMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |