Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498466 | 0.81 | CES1 (0.45) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL245524 | 0.79 | NPSR1 (0.41) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9611270 | 0.78 | KMT2A (0.62) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8946139 | 0.77 | KMT2A (0.60) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3283283 | 0.77 | KMT2A (0.60) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1635424 | 0.76 | NPSR1 (0.46) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9474692 | 0.75 | KMT2A (0.58) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9500913 | 0.75 | KMT2A (0.58) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11583122 | 0.75 | KMT2A (0.58) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4741531 | 0.75 | NPSR1 (0.50) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303515-A2 | TRICYCLIC 2-PYRIDONE COMPOUNDS USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Bristol-Myers Squibb Pharma Company (US) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002008226-A2 | TRICYCLIC 2-PYRIDONE COMPOUNDS USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2002-01-31 | — | — | WO | disclosed |