Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7034822 | 0.82 | KCNH2 (0.40) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7034821 | 0.82 | KCNH2 (0.40) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7136939 | 0.81 | KDM4E (0.43) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7034824 | 0.81 | KCNH2 (0.39) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7090591 | 0.76 | ALDH1A1 (0.45) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6994695 | 0.76 | KCNH2 (0.38) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6993770 | 0.75 | KDM4E (0.60) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7032087 | 0.75 | KDM4E (0.60) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7032100 | 0.75 | KDM4E (0.60) | KCNH2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6993777 | 0.75 | KDM4E (0.60) | KCNH2ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |