Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 6/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089986 | 0.95 | SMN1; SMN2 (0.63) | TP53SMN1; SMN2MAPTEPHX2HIF1A | |
| SCHEMBL8282242 | 0.81 | TP53 (0.78) | TP53SMN1; SMN2MAPTEPHX2HIF1A | |
| Cyclopropane SCHEMBL2444392 | 0.79 | STK17B (0.44) | TP53SMN1; SMN2MAPTEPHX2TSHR | |
| Cyclopropane SCHEMBL2438672 | 0.79 | TP53 (0.49) | TP53SMN1; SMN2MAPT | |
| SCHEMBL17404483 | 0.78 | SMN1; SMN2 (0.56) | TP53SMN1; SMN2MAPTEPHX2HIF1A | |
| SCHEMBL896377 | 0.77 | TP53 (0.56) | TP53SMN1; SMN2MAPTEPHX2HIF1A | |
| SCHEMBL3766399 | 0.77 | FAAH (0.67) | TP53SMN1; SMN2MAPTEPHX2FAAH | |
| SCHEMBL2125837 | 0.76 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTEPHX2HIF1A | |
| SCHEMBL2438375 | 0.76 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTEPHX2HIF1A | |
| SCHEMBL14427258 | 0.76 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTEPHX2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893589-B1 | SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-09-14 | — | — | EP | claimed |
| EP-1893589-B1 | SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-09-14 | — | — | EP | disclosed |
| EP-1893589-A1 | SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006131296-A1 | SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2006-12-14 | — | — | WO | disclosed |