Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrapropylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 4/20 | 0.77 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrapropylammonium SCHEMBL11636910 | 0.96 | SLC22A1 (0.71) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL7903316 | 0.92 | SLC22A1 (0.77) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL107528 | 0.92 | SLC22A1 (0.91) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL27781730 | 0.88 | SLC22A1 (0.83) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL11050419 | 0.88 | SLC22A1 (0.83) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL59838 | 0.88 | SLC22A1 (1.00) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL5490456 | 0.88 | SLC22A1 (1.00) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL15414074 | 0.85 | SLC22A1 (0.77) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL28834139 | 0.85 | SLC22A1 (0.77) | SLC22A1SLC22A2DNM1ALDH1A1TP53 | |
| Tetrapropylammonium SCHEMBL28229568 | 0.85 | SLC22A1 (0.77) | SLC22A1SLC22A2DNM1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582707-B1 | BRANCHED AROMATIC CARBONATE POLYMER | GEN ELECTRIC (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-0582707-A1 | BRANCHED AROMATIC CARBONATE POLYMER | GENERAL ELECTRIC COMPANY (US) | 1994-02-16 | — | — | EP | disclosed |
| US-5262511-A | Branched aromatic carbonate polymer | GENERAL ELECTRIC CO. (US) | 1993-11-16 | — | — | US | disclosed |
| WO-1993018082-A1 | BRANCHED AROMATIC CARBONATE POLYMER | GENERAL ELECTRIC COMPANY (US) | 1993-09-16 | — | — | WO | disclosed |
| US-4474999-A | Phenol compounds, process and polymers | GENERAL ELECTRIC COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| US-4415725-A | MOLDING MATERIALS; BLOW MOLDING; BOTTLES; FILMS | GENERAL ELECTRIC CO. (US) | 1983-11-15 | — | — | US | disclosed |
| US-4415723-A | Randomly branched aromatic polycarbonate from triphenol | GENERAL ELECTRIC COMPANY (US) | 1983-11-15 | — | — | US | disclosed |
| US-4415722-A | Branched aromatic polycarbonate from aliphatic polyol | GENERAL ELECTRIC COMPANY (US) | 1983-11-15 | — | — | US | disclosed |
| US-4415724-A | Branched aromatic polycarbonate from tetraphenol | GENERAL ELECTRIC COMPANY (US) | 1983-11-15 | — | — | US | disclosed |