Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.59 |
| ▸ | PDE4A | P27815 | 11/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.59 |
| ▸ | PDE5A | O76074 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090590 | 0.92 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7089270 | 0.86 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6154427 | 0.86 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7092998 | 0.84 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1388196 | 0.84 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7020690 | 0.84 | PDE4A (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7738936 | 0.82 | PDE4A (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7325107 | 0.81 | PDE5A (0.49) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL7423652 | 0.79 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6155745 | 0.79 | PDE4A (0.79) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799040-B1 | TRISUBSTITUTED THIOXANTHINES | EURO CELTIQUE SA (LU) | 2003-08-20 | — | — | EP | claimed |
| US-5977119-A | Trisubstituted thioxanthines | EURO-CELTIQUE, S.A. (LU) | 1999-11-02 | — | — | US | claimed |
| EP-0799040-A4 | TRISUBSTITUTED THIOXANTHINES | EURO CELTIQUE SA (LU) | 1998-04-01 | — | — | EP | claimed |
| EP-0799040-A1 | TRISUBSTITUTED THIOXANTHINES | Euroceltique S.A. (LU) | 1997-10-08 | — | — | EP | claimed |
| WO-1996018400-A1 | TRISUBSTITUTED THIOXANTHINES | EURO-CELTIQUE, S.A. (LU) | 1996-06-20 | — | — | WO | claimed |
| EP-0799040-B1 | TRISUBSTITUTED THIOXANTHINES | EURO CELTIQUE SA (LU) | 2003-08-20 | — | — | EP | disclosed |
| US-6268373-B1 | ENZYME INHIBITORS | EURO-CELTIQUE S.A. (LU) | 2001-07-31 | — | — | US | disclosed |
| US-6025361-A | EFFECTIVE PDE IV INHIBITORS, ASTHMA | EURO-CELTIQUE, S.A. (LU) | 2000-02-15 | — | — | US | disclosed |
| US-5977119-A | Trisubstituted thioxanthines | EURO-CELTIQUE, S.A. (LU) | 1999-11-02 | — | — | US | disclosed |
| EP-0799040-A4 | TRISUBSTITUTED THIOXANTHINES | EURO CELTIQUE SA (LU) | 1998-04-01 | — | — | EP | disclosed |
| EP-0799040-A1 | TRISUBSTITUTED THIOXANTHINES | Euroceltique S.A. (LU) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996018400-A1 | TRISUBSTITUTED THIOXANTHINES | EURO-CELTIQUE, S.A. (LU) | 1996-06-20 | — | — | WO | disclosed |