Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677655 | 0.89 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29354661 | 0.88 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL29721014 | 0.88 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7962095 | 0.85 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6672389 | 0.84 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6675074 | 0.83 | PDE4B (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6675460 | 0.82 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6675826 | 0.82 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6672384 | 0.82 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7092998 | 0.81 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202628-B1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO CELTIQUE SA (LU) | 2004-10-13 | — | — | EP | claimed |
| EP-0912575-B1 | PROCESSES FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO CELTIQUE SA (LU) | 2005-02-02 | — | — | EP | disclosed |
| EP-1202628-B1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO CELTIQUE SA (LU) | 2004-10-13 | — | — | EP | disclosed |
| EP-1045849-B1 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2003-07-02 | — | — | EP | disclosed |
| EP-1202628-A4 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | EP | disclosed |
| EP-1202628-A1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | Euro-Celtique S.A. (LU) | 2002-05-08 | — | — | EP | disclosed |
| EP-1045849-A4 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO CELTIQUE SA (LU) | 2001-10-31 | — | — | EP | disclosed |
| US-6310205-B1 | Hypoxathine compounds | EURO-CELTIQUE, S.A. (LU) | 2001-10-30 | — | — | US | disclosed |
| US-6228859-B1 | ANTIASTHMATIC, ANTIINFLAMMATORY, ANTIALLERGEN AND ANTIDEPRESSANT AGENTS | EURO-CELTIQUE S.A. (LU) | 2001-05-08 | — | — | US | disclosed |
| EP-0912575-A4 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO CELTIQUE SA (LU) | 2001-04-25 | — | — | EP | disclosed |
| WO-2001011967-A1 | NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2001-02-22 | — | — | WO | disclosed |
| EP-1045849-A1 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | Euro-Celtique S.A. (LU) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999031102-A1 | PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY | EURO-CELTIQUE, S.A. (LU) | 1999-06-24 | — | — | WO | disclosed |
| EP-0912575-A1 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | Euro-Celtique S.A. (LU) | 1999-05-06 | — | — | EP | disclosed |
| US-5864037-A | Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity | EURO-CELTIQUE, S.A. (LU) | 1999-01-26 | — | — | US | disclosed |
| WO-1997046561-A1 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO-CELTIQUE, S.A. (LU) | 1997-12-11 | — | — | WO | disclosed |