Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084132 | 0.91 | PTGS2 (0.54) | PTGS2PTGS1ESR1ESR2ALDH1A1 | |
| SCHEMBL7085382 | 0.91 | PTGS2 (0.54) | PTGS2PTGS1ESR1ESR2ALDH1A1 | |
| SCHEMBL7084147 | 0.90 | PTGS2 (0.54) | PTGS2PTGS1ESR1ESR2 | |
| SCHEMBL7087503 | 0.90 | PTGS2 (0.54) | PTGS2PTGS1ESR1ESR2 | |
| SCHEMBL7091285 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1ESR1ESR2ALDH1A1 | |
| SCHEMBL7085171 | 0.87 | PTGS2 (0.54) | PTGS2PTGS1ESR1ESR2ALDH1A1 | |
| SCHEMBL7088103 | 0.86 | PTGS1 (0.55) | PTGS2PTGS1ESR1ESR2ALDH1A1 | |
| SCHEMBL7087564 | 0.86 | MAPK14 (0.58) | PTGS2PTGS1ESR1ESR2MAPK14 | |
| SCHEMBL7084863 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1ESR1ESR2ALDH1A1 | |
| SCHEMBL6739064 | 0.85 | ESR1 (0.40) | PTGS2PTGS1ESR1ESR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030050330-A1 | 4,5-subtstituted imdazolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. | 2003-03-13 | — | — | US | disclosed |
| US-6426360-B1 | ANTIARTHRITIC AGENTS | G D SEARLE & CO. | 2002-07-30 | — | — | US | disclosed |
| EP-1211244-A2 | 4,5-substitued imidazolyl compounds for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030050330-A1 | 4,5-subtstituted imdazolyl compounds for the treatment of inflammation | AHR, HACL2, IRAK2 | PTGS2 122/4885PTGS1 114/4885ESR1 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.