Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143604 | 0.86 | DEGS1 (0.65) | POLBTSHRLMNARAB9ASMN1; SMN2 | |
| SCHEMBL22607251 | 0.83 | RAB9A (0.59) | POLBTSHRALDH1A1LMNARAB9A | |
| SCHEMBL31307412 | 0.82 | POLB (0.51) | POLBTSHRALDH1A1LMNARAB9A | |
| SCHEMBL23608334 | 0.82 | POLB (0.51) | POLBTSHRALDH1A1LMNARAB9A | |
| SCHEMBL24616597 | 0.82 | SMN1; SMN2 (0.54) | POLBTSHRALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL16755148 | 0.82 | GCK (0.50) | POLBTSHRRAB9ASMN1; SMN2MAPT | |
| SCHEMBL7095081 | 0.81 | GCK (0.52) | POLBTSHRALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL18216846 | 0.80 | TRPV1 (0.52) | POLBTSHRALDH1A1LMNARAB9A | |
| SCHEMBL22607138 | 0.80 | MEN1 (0.49) | POLBTSHRLMNARAB9ASMN1; SMN2 | |
| SCHEMBL8986532 | 0.80 | RAB9A (0.59) | TSHRRAB9AMAPTNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842924-B1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER (US) | 2003-08-20 | — | — | EP | disclosed |
| US-6031105-A | Substituted pyridines | PFIZER INC (US) | 2000-02-29 | — | — | US | disclosed |
| US-6008361-A | Substituted pyridines | PFIZER INC. (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0842924-A1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER INC. (US) | 1998-05-20 | — | — | EP | disclosed |