Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366144 | 0.95 | PDE4B (0.50) | PDE4BPRMT5WDR77USP30CHEK2 | |
| SCHEMBL5414961 | 0.95 | PDE4B (0.50) | PDE4BPRMT5WDR77USP30CHEK2 | |
| SCHEMBL14559939 | 0.95 | PDE4B (0.50) | PDE4BPRMT5WDR77USP30CHEK2 | |
| SCHEMBL1927899 | 0.88 | USP30 (0.52) | PDE4BPRMT5WDR77USP30GPR119 | |
| SCHEMBL3954269 | 0.83 | USP30 (0.47) | PDE4BPRMT5WDR77USP30GPR119 | |
| SCHEMBL5371739 | 0.82 | PDE4B (0.52) | PDE4BPRMT5WDR77USP30CHEK2 | |
| SCHEMBL69206 | 0.81 | KDM1A (0.56) | PDE4BGPR119KDM1A | |
| SCHEMBL15058781 | 0.81 | PRMT5 (0.50) | PDE4BPRMT5WDR77USP30CHEK2 | |
| SCHEMBL15058778 | 0.81 | PRMT5 (0.50) | PDE4BPRMT5WDR77USP30CHEK2 | |
| SCHEMBL23754388 | 0.80 | DGAT2 (0.57) | PDE4BPRMT5WDR77USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370558-A1 | PIPERAZINE- AND PIPERIDINE-DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002059117-A1 | PIPERAZINE- AND PIPERIDINE-DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |